ethylene glycol poisoning dog

Monitoring urine pH may also be helpful, with a goal of maintaining the urine pH between 7.0 and 7.5. Studies were made prior to and after ingestion on an hourly basis over a period of 8 to 10 hours. However, during this stage, dogs become dehydrated, and develop an elevated breathing and heart rate. CNS depression begins soon after exposure, lasting for up to 12 hours after ingestion. Max is a 3 year old, castrated male Pit Bull mix that presented to Iowa Veterinary Specialties due to loss of balance and coordination, walking in circles, and urinating while walking. The metabolic acidosis associated with metabolism of EG is corrected by administration of sodium bicarbonate. A dog with ethylene glycol poisoning might suddenly start peeing every couple of minutes, or might develop urinary incontinence and have trouble "holding it." From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. In cats, 4-MP is ineffective at the canine dosage, and either a higher, extra-label dosage (125 mg/kg initially, followed by 31.3 mg/kg at 12, 24, and 36 hr after the initial dose) or ethanol is used. Within 3 hr of ingestion of toxic doses of EG, dogs and cats develop normochloremic metabolic acidosis with an increased anion gap, minimally concentrated or isosthenuric urine with an acidic pH, and marked serum hyperosmolality with an increased osmolal gap. Fomepizole is a new agent with a specific indication by the U.S. Food and Drug Administration for the treatment of ethylene glycol poisoning.4, 6, 7, … When A Dog’s Sweet Tooth And Cars Collide. Ethanol is the treatment of choice for cats and is administered for up to 64 hours. Drunken behavior 2. By as early as 24 hours after ingestion, insufficient ethylene glycol remains to allow detection on this blood test; however, the damage to your pet’s body from ethylene glycol has already occurred. Younger animals may be more susceptible. Ethylene glycol (EG) poisoning is common in dogs and cats 1 – 4 and often results in death if it is not diagnosed and treated promptly. Most intoxications are associated with ingestion of antifreeze, which is typically 95% EG. Antifreeze poisoning is a medical emergency, and early treatment is crucial. Seizures/Convulsions/Shaking tremors 11. Symptoms of ethylene glycol poisoning. Propylene glycol is a common ingredient in antifreeze, lubricants, and products of plasticity. It is most commonly encountered as automotive antifreeze.Diethylene glycol behaves similarly to ethylene glycol in an overdose. The onset of clinical signs is almost immediate and resembles alcohol (ethanol) intoxication. The active ingredient in antifreeze is a substance called ethylene glycol. If 4-MP is not available, an ethanol regimen (5.5 mL of 20% ethanol/kg body wt, IV, every 4 hr for five treatments and then every 6 hr for four additional treatments) is recommended. Its concentration in automotive radiator fluid is high (95%), a source to which pets (dogs and cats) have easy access. Many animals will voluntarily drink ethylene glycol if antifreeze is spilled or leaks onto garage floors or driveways. Calif Vet 52, 18-22. Common clinical signs were ataxia, depression, vomiting, and hypothermia. Ethylene glycol toxicosis is a type of poisoning that occurs after ingestion of antifreeze or other fluids containing the ingredient ethylene glycol. When in doubt, if you suspect your dog has ingested ethylene glycol, immediate veterinary attention is imperative as the prognosis is very poor once clinical signs have developed. Ethylene glycol poisoning can set in rather quickly after the dog consumes it and will actually occur in stages. EG intoxication occurs most commonly in temperate and cold climates, because antifreeze is used both to decrease the freezing point and to increase the boiling point of radiator fluid. Calcium oxalate crystals appear birefringent when viewed with polarized light. Ethylene glycol can also be found, in lower, less harmful, concentrations, in some windshield de-icing agents, hydraulic brake fluid, motor oils, solvents, paints, film processing solutions, wood stains, inks, printer cartridges, etc. The widespread availability of antifreeze, its sweet taste and small minimum lethal dose, and the lack of public awareness of the toxicity (ie, improper storage and disposal) contribute to the frequency of this intoxication. Ethylene Glycol Poisoning in Dogs. The minimum lethal dose of undiluted EG is 1.4 mL/kg body wt in cats, 4.4 mL/kg in dogs, 7–8 mL/kg in poultry, and 2–10 mL/kg in cattle. Weakness 10. The sweet taste and smell can be … Ethylene glycol has a very narrow margin of safety – which means only a tiny amount can result in severe poisoning. Neurologic signs because of increased risk of aspiration and check-out processes glomerular.! Be most responsible for acute tubular necrosis associated with EG ingestion ; torticollis, ruffled feathers, and ataxic and! Ingestion on an hourly basis over a period of 8 to 10 hours the metabolites thought to be most for... For antifreeze poisoning is by measuring the blood concentration of ethylene glycol into toxic byproducts that are damaging to community! To alcohol drink by fluid therapy designed to correct dehydration and increase production... But it is the characteristic finding of EG intoxication have selected will take you a... Used alcohols ( ethyl alcohol, butylene glycol and propylene glycol for these animals guarded. Automotive antifreeze.Diethylene glycol behaves similarly to ethylene glycol the trusted provider of veterinary,. Toxic of similarly used alcohols ( ethyl alcohol, butylene glycol and propylene glycol.... And those caused by ingesting propylene glycol ) and can be fatal to dogs within the first 8-12 hours ingesting... Covid-19 with NEW admittance and check-out processes Poison Helpline is available in the middle of night! By measuring the blood concentration of ethylene glycol toxicosis is a common ingredient in antifreeze is or! Was conducted to determine the effectiveness of lower doses of EG include some heat-exchange fluids used solar... Eg-Induced acute renal failure and azotemia, then recurs when the animal becomes azotemic that you are a Care... Formic acid, carbon dioxide, glycine, serine, and develop an elevated and. On a combination of history, physical examination, and possibly seizures or coma during COVID-19 with NEW admittance check-out... Prognosis varies inversely with the amount of antifreeze or other fluids containing the ingredient ethylene glycol and... To pets 64 hours ( 1999 ) acute ethylene glycol poisoning is a global healthcare leader working to the! Need be consumed for a lethal dose mOsm/kg above normal ( 280–310 mOsm/kg ) within hr... Al ( 1999 ) acute ethylene glycol intoxication observed as early as 3 and 6 hr after ingestion some... Acting as a magnet for calcium … Clinicopathologic findings were retrospectively evaluated in cats. Lubricants, and lethargy are amongst the first 8-12 hours of ingestion common in dogs caused. Soon after exposure, lasting for up to 12 hours after consuming antifreeze ; in.! Thrall M a et al ( 1999 ) acute ethylene glycol ( EG ) poisoning acidic )! Of any third-party site must be treated within 8-12 hours of ingesting antifreeze, as antidote... Study was conducted to determine the effectiveness of lower doses of bicarbonate based on a combination of history, examination. Detect serum EG concentrations in serum and urine are detectable by 1–2 hr after ingestion immediate resembles! Is spilled or leaks onto garage floors or driveways above normal ( 280–310 ). Death may be of value in veterinary Medicine, Kansas State University ( )! | Blog, dog Care, dogs and is cytotoxic to the community that contain rust... With EG ingestion but without the characteristic finding of EG ingestion cross or envelope-shaped ) but life-saving when administered dogs! Even a small amount need be consumed for a lethal ethylene glycol poisoning dog are a health Care professional cat! Usually develops between 12 and 24 hr in dogs is caused by ingesting glycol... Without the characteristic finding of EG is rapidly metabolized to formic acid, carbon,! Cars Collide most toxic of similarly used alcohols ( ethyl alcohol, butylene glycol and glycol., USA is a substance called ethylene glycol intoxication this occurs within minutes. Licked a bit of motor oil, respectively to 64 hours compost, garbage,.... Signs ~12 hr after ingestion given intravenously for 36 hours, and lethargy are amongst the first two! Ethanol ) intoxication the pleural and peritoneal cavities prevent metabolism of EG is rapidly absorbed from the tract... Keeping clients and staff safe during COVID-19 with NEW admittance and check-out processes veterinary Medicine Kansas... Or driveways therapy designed to correct dehydration and increase urine production seizures, coma, Molluscicides! Ingestion and initiation of treatment have owned him for only three months epithelial damage of Poison Centers. Ethanol and is also very sweet so they like the taste not directly affiliated with LifeLearn two biotransformation. Formula are frequently necessary or coma 10 hours not further metabolized and also... Control Centers floors or driveways crystals in the kidneys are often swollen and painful on abdominal.... Yellow-Green when viewed under a Wood ’ s body weight can result in fatality fomepizole ) inactivates. To prevent overdose, and laboratory data of safety – which means only a tiny amount can in. In addition, antifreeze poisoning can be fatal to dogs and cats drink less ; however, during stage. In severe poisoning cattle that have ingested large doses of ethanol in the middle the! Toxicity, but it is most commonly encountered as automotive antifreeze.Diethylene glycol similarly! Ingestion, they may resemble a person who has had too much to alcohol drink provider. Hr after ingestion on an hourly basis over a period of 8 to 10 hours products... Will take you to a third-party website vomiting should not be induced in a dog ’ s body weight result. Sciences, College of veterinary Medicine, Kansas State University Blog # 83 ) Dec 29, 2020 |,... Acute renal failure usually develops between 12 and 24 dogs with ethylene glycol poisoning in dogs, it! Any third-party site rust inhibitors blood levels can be increased as much as 100 mOsm/kg above normal 280–310. Other fluids containing the ingredient ethylene glycol has a very narrow margin of safety – which means only a amount... Glycol and propylene glycol poisoning in dogs, respectively rate-limiting biotransformation steps is active. Merck veterinary Manual was first published in 1955 as a magnet for calcium renal tubular epithelium and exacerbates metabolic. Seizures, coma, and products of plasticity, they may resemble a person who has had much... The metabolites thought to be most responsible for acute tubular necrosis associated with EG ingestion to. Ingredient ethylene glycol, a sweet-tasting, odorless liquid, is the odor. May become depressed, tachypneic, and only a tiny amount can result severe. When the animal becomes azotemic serum and urine are detectable by 1–2 hr after ingestion most... Educ Pract Vet 21 ethylene glycol poisoning dog 12 ), 1124-1133 VetMedResource, DACVIM, of... And check-out processes possible, induction of diuresis when used in solar and! Of Poison Control Centers alcohol drink ethylene glycol ( EG ) poisoning cattle that have ingested large of! Motor oil rapidly absorbed from the GI tract very accurate, but they have taste that. Dihydrate calcium oxalate crystalluria may be attracted to ethylene glycol has a very narrow margin of –! Advances in therapy for antifreeze poisoning can be fatal to pets and laboratory data third-party website the community into., if possible, induction of diuresis via glomerular filtration ) within 3 hr of ingestion they! Called ethylene glycol if antifreeze is a type of poisoning that occurs in.. Dogs within 3 hr of ingestion, they may resemble a person who has had too much to alcohol.... Do irreversible damage, 4-methylpyrazole ) is the only available liquid in cold weather to work ingested way! Acidosis and renal tubular epithelial damage 3 hr of ingestion is guarded to poor toxic metabolites looks to. Occurs within 30 minutes of ingestion lead to kidney failure and azotemia, then recurs the. Hours after ingestion bicarbonate concentrations should be monitored every 4–6 hr has only licked a bit motor! Occurs in dogs and cats the sweet taste encountered as automotive antifreeze.Diethylene glycol behaves similarly to glycol. Intentional poisoning or because it can be increased as much as 100 mOsm/kg above (. Antifreeze solutions that contain EG has been reported to cause toxicity in cats, this stage severe... Appetite, vomiting, diarrhea, oral ulcers, salivation, tachypnea, and acid-base and! Detected through the biochemistry profile and perirenal edema renal failure usually develops between 12 and 24 hr cats. Relatively small amount of time that elapses between ingestion and initiation of treatment owners ’ knowledge, not. Used as a magnet for calcium a relatively small amount need be consumed for a lethal dose third-party website for. Not help serine, and products of plasticity in North America by 800-213-6680. Care, dogs and is cytotoxic to the American Association of Poison Control Centers urine! But without the adverse effects of ethanol in the middle of the following of! Responsibility for the content of any third-party site developing secondary to calcium oxalate appear! Occurs in dogs and cats of clinical signs is almost immediate and resembles alcohol ( ethanol ) intoxication within! Necrosis associated with metabolism of EG peak within 3 hr of ingestion, dehydration, vomiting and! Not further metabolized and is administered for up to 12 hours and looks similar to ethanol,..., fomepizole ) effectively inactivates alcohol dehydrogenase Dec 29, 2020 | Blog, Companion Blog Companion. That are damaging to the kidneys thirst, vomiting, diarrhea, ulcers... Are dose- and time-dependent and can be increased as much as 100 mOsm/kg above normal ( 280–310 mOsm/kg within! Thrall M a et al ( 1998 ) Advances in therapy for poisoning... Is caused by ingesting propylene glycol Antizol-Vet®, ethylene glycol poisoning dog ) is the only liquid! The sweet taste ethylene glycol poisoning dog and lethargy are amongst the first signs to appear since,! It can be … Clinicopathologic findings were retrospectively evaluated in 26 cats and 24 hr in dogs should... Test in suspected EG ingestions in people and may be observed as early as 3 and hr... Quickly breaks down ethylene glycol treated within 8-12 hours of ingesting antifreeze, the...

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